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  Home > JCE Print > Journal of Chemical Education > Issues > 2002  > January  >
In the Laboratory
Second-Year and AP Chemistry
Modeling the Drug Discovery Process: The Isolation and Biological Testing of Eugenol from Clove Oil
William H. Miles
Department of Chemistry, Lafayette College, Easton, PA 18042

Patricia M. Smiley
Southern Lehigh High School, Center Valley, PA 18034

Cover
January 2002
Vol. 79 No. 1
p. 90
Abstract
This experiment describes the isolation and biological testing of eugenol and neutral compounds from commercially available clove oil. By coupling the chemical separation of the components of clove oil (an experiment described in many introductory organic laboratory textbooks) with a simple antibiotic test, the students "discover" the biologically active compound in clove oil. This experiment models one of the primary methods used in the discovery of new pharmaceutical agents.
Supplement
Background information, experimental procedures, notes for instructors, photographs, and a lab report form are available.
*  Contents JCE2002p0090W.doc (Microsoft Word)
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More Information
*  Citation
 Miles, William H.; Smiley, Patricia M. J. Chem. Educ. 2002 79 90.
*  Keywords
 Acid?Base Chemistry; Drugs / Pharmaceuticals; Introductory / High School Chemistry; Laboratory Instruction; Medicinal Chemistry; Natural Products; Organic Chemistry; Separation Science
*  History
 Created:
Last Updated:		 December 3, 2001
March 16, 2005
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