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  Home > JCE Print > Journal of Chemical Education > Issues > 2006  > December  >
Chemistry for Everyone
Products of Chemistry
Nature's Way To Make the Lantibiotics
Heather A. Relyea and Wilfred A. van der Donk
Department of Chemistry, University of Illinois, Urbana, IL 61801
Cover
December 2006
Vol. 83 No. 12
p. 1769
Abstract
Antibiotic resistance poses a serious threat for human health. Renewed effort towards discovery of new antibiotics is essential to ward off a widespread return of lethal infectious diseases to the developed world and to continue combating infectious diseases in the developing world. Traditionally, chemical education focuses on synthetic chemical means of producing pharmaceuticals. However, with the enormous advances in molecular biology techniques in the 1980s and genome sequence information in the 1990s, the use of nature's synthetic tools is on the rise as an important alternative avenue for production of drugs. This article focuses on one class of antimicrobial compounds, the lantibiotics, and discusses their biosynthetic pathways as well as their molecular mode of action. In the course of the review, the meaning of the terms regio-, chemo-, and stereoselectivity are discussed.
More Information
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Citation
Relyea, Heather A.; van der Donk, Wilfred A. J. Chem. Educ. 2006 83 1769.
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Keywords
Applications of Chemistry; Biochemistry; Bioorganic Chemistry; Biosynthesis; Biotechnology; Catalysis; Drugs / Pharmaceuticals; First-Year Undergraduate / General; High School / Introductory Chemistry; Organic Chemistry; Proteins / Peptides; Second-Year Undergraduate; Textbooks / Reference Books
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History
Created:
Last Updated:
10/30/2006
10/31/2006
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