TOPIC: 19. Carboxylic Acids

SUBTOPIC: 190. Acyl Chlorides

 

5144

 

A drug whose physiological effects are similar to those of aspirin may be prepared by heating p-methoxybenzoyl chloride with an equimolar quantity of phenol in the presence of an excess of suitable organic base to act as a proton acceptor and solvent.  Identify an appropriate organic base, and write the structure of the product in this reaction.