TOPIC: 19. Carboxylic Acids

SUBTOPIC: 199. Mechanisms of Reactions

5062

Suggest a mechanism for each of the following reactions:

(a)

(b)

5238

Propose a step-by-step mechanism for the acid-catalyzed esterification of acetic acid with ¹⁸O-labeled methanol consistent with the observation that the alcohol oxygen becomes bonded to the carboxy carbon atom.