TOPIC: 23. Lipids

SUBTOPIC: 233 Steroids

5125

There is much evidence from cell-free systems that squalene is converted to the 2,3-oxide which undergoes enzyme-mediated cyclization. Show how such cyclization could lead to lanosterol.

Squalene

Lanosterol

5132

What reagent(s) is/are necessary for the reaction which occurs as the last step of the Johnson synthesis of the sex hormone progesterone?

progesterone