 |
|
|
|
|
||
| Special Issue 13 | ||
|
|
||
| In This Issue | ||
|
|
||
| HIV-1 Protease: An Enzyme at Work | ||
|
|
Erica Bode Jacobsen Institute for Chemical Education, University of Wisconsin-Madison, Madison, WI 53706-1396 Jerrold J. Jacobsen and J. Monty Wright University of Wisconsin-Madison, Madison, WI 53706-1396
|
|
|
|
||
| About This Issue | ||
|
John W. Moore and Jon L. Holmes University of Wisconsin-Madison, Madison, WI 53706-1396 |
||
|
|
||
|
Note: |
Order Item Number: SP-13 |
|
|
|
||
|
How to Use These Materials Any classroom where there is discussion of kinetics, catalysis, proteins, enzymes, or HIV would benefit from the materials in this issue. The computer animations show state-of-the-art molecular modeling, and so this issue can be used effectively at levels from high school chemistry or biology through advanced undergraduate courses.
In textbooks the two-dimensional portrayal of the action of enzymes does not give a clear picture of this three-dimensional process. The lock-and-key diagram commonly used (1, 2) gives no hint to the real-life binding process and conformation changes that enzymes, inhibitors, and substrates undergo. A portrayal of enzymatic processes through computer animations converted to videotape allows students to easily visualize the three-dimensional workings of an enzyme system. Since HIV is a current topic, discussion of the protease and a possible cure for HIV is an excellent way to relate science to life outside of the classroom. The topic also helps student realize that scientists do not have all the answers. Research on the protease is a continuous, never-ending process. Hardware and Software Requirements This is the first special issue of JCE: Software to include a videotape. It consists of a standard VHS videotape together with written materials that support the tape's use in the classroom. The videotape is closed captioned. Because the video tells a continuous, linear story, the videotape medium is convenient and effective, but we expect eventually to make specific animated sequences available on random-access videodisc as well. A standard VHS VCR and a monitor or projection system that will produce an image large enough for all students to view clearly and will play the audio track are the only hardware items required. Literature Cited Availability
Available: Now
|
||
|
|
|
|
|
|
|
|
|
|
Last Updated: March 19, 2001 Created: December 10, 1996 |
Created by: J.L. Holmes Comments to: jceonline@chem.wisc.edu |
|
|
|
| © 1997 Division of Chemical Education, Inc., American Chemical Society. All rights reserved. | |