Synthesis and Kinetics of Hydrolysis of 3,5-Dimethyl-N-acetyl-p-benzoquinone Imine: An Undergraduate Laboratory
Jeanne M. Buccigross, Christa Metz, Lori Elliot, Pamela Becker, Angela S. Earley, Jerry W. Hayes
College of Mount St. Joseph, Cincinnati, OH 45233-1670
Michael Novak, and Gayl A. Underwood
Miami University, Oxford, OH 45056
The synthesis of the title compound by a three-step procedure is described. The hydrolysis kinetics, which involve two consecutive psuedo-first-order processes, are also described. The synthesis and kinetics experiments described here are proposed for incorporation into undergraduate laboratory courses under a variety of formats. The compound described here is related to a toxic metabolite of the common analgesics acetaminophen and phenacetin.
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Citation
Buccigross, Jeanne M.; Metz, Christa; Elliot, Lori; Becker, Pamela; Earley, Angela S.; Hayes, Jerry W.; Novak, Michael; Underwood, Gayl A. J. Chem. Educ.1996 73 364.
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