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  Home > JCE Print > Journal of Chemical Education > Issues > 1996  > February  >
Features
Computer Series
Computer-Modelling of Metal Speciation in Human Blood Serum
Peter Letkeman
Brandon University, Brandon, Manitoba, Canada R7A 6A9
Cover
February 1996
Vol. 73 No. 2
p. 165
Abstract
This paper briefly describes two computer programs, BEST and ECCLES, both available on disc, that can generate distribution diagrams for various metal-complexes in human blood plasma. Two heavy metals, lead and mercury, are used as examples. The species distribution vs pH diagrams are based on formation constants obtained from our own potentiometric study of the mercury-glutathione system. The efficacy of a chelating agent for mobilizing a metal ion from the liable metal-protein complex portion of blood, PMI index, is discussed as well. The paper points out that computer modelling of metal speciation in human blood plasma has led to the design of important new therapeutic chelating agents.
More Information
*  Citation
 Letkeman, Peter. J. Chem. Educ. 1996 73 165.
*  Keywords
*  History
 Created:
Last Updated:		 9/25/1999
5/22/2006
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