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  Home > JCE Print > Journal of Chemical Education > Issues > 1997  > August  >
In the Laboratory
An Undergraduate Organic Chemistry Laboratory Experiment: The Multistep Synthesis of a Modified Nucleoside
Peter deLannoy and Joseph Howell
Department of Chemistry, Black Hills State University, Spearfish, SD 57799
Cover
August 1997
Vol. 74 No. 8
p. 990
Abstract
We have designed and integrated the multistep synthesis of a modified nucleoside into an undergraduate organic chemistry laboratory. The laboratory was designed as a multidisciplinary approach towards a single synthetic problem. Here we report the synthesis and subsequent purification of 5'-O-dimethoxytrityl-2'-O-methyluridine and 5'-O-dimethoxytrityl-3'-O-methyluridine directly from the literature by a protocol that is appropriate in a small school setting.
More Information
*  Citation
 deLannoy, Peter; Howell, Joseph . J. Chem. Educ. 1997 74 990.
*  Keywords
 Organic Chemistry, Biochemistry, Bioorganic/Bioinorganic, Chromatography, Medicinal Chemistry, Nucleic Acids
*  History
 Created:
Last Updated:		 July 28, 1999
June 23, 2005
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  Home > JCE Print > Journal of Chemical Education > Issues > 1997 > August > Page 990


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