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1997
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February
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In the Laboratory
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Simulation and Analysis of Differential Scanning Calorimetry Output: Protein Unfolding Studies
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Babur Chowdhry
School of Biological and Chemical Sciences, University of Greenwich, Wellington Street, Woolwich, London, SE18 6PF, UK
Stephen Leharne
School of Environmental Sciences, University of Greenwich, Creek Road, Deptford, London, SE8 3BW, UK
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February 1997
Vol. 74 No. 2
p. 236
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| Abstract |
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High sensitivity differential scanning calorimetry ( HSDSC ) is a
powerful and increasingly used technique for the study of molecular
energetics in relation to biopolymers (e.g. proteins and nucleic
acids ) or biomacromolecular assemblies ( e.g. liposomes ).
HSDSC is, for example, the only method which allows thermodynamic
parameters to be obtained directly for protein unfolding.
The thermodynamic basis for HSDSC signals obtained for the
equilibrium unfolding of proteins as well as the formalism for
generating simulations of HSDSC outputs for protein unfolding are
discussed. This will allow students ( studying biophysical chemistry,
biochemistry, biophysics, molecular biology and allied subjects at
undergraduate and postgraduate level ) to obtain an understanding of
the type of data analysis required for HSDSC experiments on
proteins.
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| More Information |
 Citation |
Chowdhry, Babur; Leharne, Stephen. J. Chem. Educ. 1997 74 236.
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Keywords |
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History |
Created:
Last Updated: |
July 29, 1999
June 23, 2005
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| Home > JCE Print > Journal of Chemical Education > Issues >
1997
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February
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236
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