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The total synthesis of a new class of compounds that promise to be cancer chemotherapeutic agents at least as effective as taxol was presented in the May 15 issue (Vol.
387, pp 238-239) as a "News and Views" article. Although structurally unrelated, epothilones, like taxol, target the microtubules of the cytoskeleton and inhibit cancer cell growth
by polymerizing these subcellular structures. Future research will have to determine which derivatives of natural epothilones are effective and which functional groups hold the key to the compounds' biological activity. An article by Deshpande and Danishefsky (May 8 issue of Vol.
387, pp 164-166) details the successful chemical synthesis of an
oligosaccharide that is frequently found on the surface of
colon adenocarcinomas. While the small quantities of this
cancer antigen that can be purified from natural sources
preclude its usefulness as an immunological tool, the synthetic
compound and an analog that can be linked to a carrier molecule
for biological delivery have potential as vaccines for several
human cancers.
The field of solid lubricant
research has received a boost with the development of elastic,
hollow nanoparticles of tungsten disulfide that are
structurally related to nested fullerenes (June 19 issue of Vol.
387, pp 791-793; see also the "News and Views" article on pp 761-763). Rapoport et
al. believe that the superior properties of the new material
can be attributed to the chemical inertness of the round
particles, which prevents their interaction with the
lubricated surface, and to their rolling motionsimilar to tiny
ball bearings, as opposed to the sliding motion of their
layered conventional counterparts. Projected applications of
the new solid lubricants lie in areas where liquid
lubricants cannot be used, such as in the temperature extremes
and vacuum found in space, and in automobile technology.
Rolling along: The round tungsten
disulfide fullerenes keep two metal surface (which
are uneven on the molecular scale) from touching one another as they move, thus reducing
friction in the machinery.
Since the publication in
Nature of the successful cloning of the sheep Dolly (as reported in our previous
column, J. Chem. Educ. 1997,
74, 490), almost every issue of the journal has featured reports of political action under
consideration in the U.S. to ban cloning of humans, and
discussions about the ethics and implications of the process for humans.
An interesting commentary by Axel Kahn on these
issues appeared in Nature 1997, 386
(March 13), 119). No end seems to be in sight for debates about the ethical, legal,
and moral aspects of generating human clones in the future!
Among the books recently reviewed in
Nature, the following caught our attention as being
particularly interesting to the chemistry educator. In
A History of Chemistry, historians Bernadette Bensaude-Vincent and
Isabelle Stengers trace the changes of the discipline from the
days of alchemy to the present (March 6 issue of Vol.
386, p 34). The Neutron and the Bomb: A Biography of Sir
James Chadwick, by Andrew Brown, details Chadwick's
scientific life from the discovery of the neutron (which earned him
a Nobel prize) to his involvement in the Manhattan
Project (Vol. 387, May 29 issue, p 467). The March 27 issue
(Vol. 386) contains the annual Spring Books supplement with reviews of many
interesting books from all areas of scienceamong them two highly
entertaining accounts of the dawn of molecular biology:
The Double Helix, by James Watson, and The Eighth Day
of Creation, by Horace Freeland Judson, which are now available in new
editions. Finally, in the April 10 issue (Vol.
386, pp 566-567), Talking about Leaving:
Why Undergraduates Leave the Sciences, by
Elaine Seymour and Nancy M Hewitt, was reviewed. The book seeks to
determine the factors that contribute to the frequently observed
change in career goals of many U.S. students, especially women and ethnic minorities,
who had begun their college careers majoring in the sciences.
Finally, we would like to direct readers' attention to
a commentary by physicist Paul M. Grant (March 13 issue
of Vol. 386, pp 115-118). The article recounts the history
of superconductivity since its discovery a little more than
a decade ago, summarizes recent advances towards
developing high-temperature, processible (i.e., less brittle)
second-generation superconducting materials, and outlines
future practical applications of this technology.
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