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  Home > JCE Print > Journal of Chemical Education > Issues > 1998  > June  >
In the Classroom
Teaching with Technology
Structural Analysis and Modeling of Proteins on the Web: An Investigation for Biochemistry Undergraduates
Darryl León, Sarah Uridil, and James Miranda
California Polytechnic State University, Department of Chemistry & Biochemistry, San Luis Obispo, CA 93407
Cover
June 1998
Vol. 75 No. 6
p. 731
Abstract
Teaching computer analysis and modeling of proteins at undergraduate universities can prepare students for their anticipated careers as future biochemists. Although there are a variety of software packages that researchers use for structural analyses of protein and nucleic acid sequences, these packages may be too complicated for undergraduates to learn within a few weeks, or they require an expensive graphics workstation to be useful. One manner to overcome such limitations is to access databases and structural analytical tools via the World Wide Web (WWW). This approach was used successfully in teaching an advanced biochemistry course (protein structure and folding) and was investigated further as an undergraduate research project. Presented here is the method used and an example where a student predicted the tertiary structure of a fragment from a DNA-binding protein after first acquiring the skills necessary to utilize the information from the Internet. This paper documents that undergraduates who do not have access to expensive modeling tools can gain some experience in protein structure determination through a computer.
More Information
*  Citation
 León, Darryl; Uridil, Sarah; Miranda, James. J. Chem. Educ. 1998 75 731.
*  Keywords
 Internet, Molecular Properties/Structure, Proteins, Biochemistry
*  History
 Created:
Last Updated:		 June 23, 1999
June 24, 2005
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