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  Home > JCE Print > Journal of Chemical Education > Issues > 1998  > March  >
Information • Textbooks • Media • Resources
Computer Bulletin Board
Use of a Spreadsheet To Simulate Enzyme Kinetics
Michael F. Bruist
Philadelphia College of Science and Pharmacy, Department of Chemistry and Biochemistry, 600 S. 43rd Street, Philadelphia, PA 19104-4495
Cover
March 1998
Vol. 75 No. 3
p. 372
Abstract
A spreadsheet with graphics capabilities is used to model enzyme kinetics and to explain how computer simulation of a reaction mechanism is accomplished by the Gauss-Cauchey method. The exercises described help illuminate the link between chemical phenomena and their mathematical description. I use these exercises in an advanced undergraduate biochemistry course. They can be done in two or three 4-hour computer laboratory sessions. The first session introduces students to spreadsheets using a simple first order reaction, the decay of 14C. Enzyme kinetics are developed in the remaining sessions using the mythical enzyme Midase. The spread sheets can be modified to illustrate more complex schemes such as inhibition or initial burst kinetics.
More Information
*  Citation
 Bruist, Michael F. J. Chem. Educ. 1998 75 372.
*  Keywords
 Biochemistry, Enzymes, Computer Assisted Instruction, Kinetics
*  History
 Created:
Last Updated:		 June 28, 1999
June 24, 2005
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