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Oxford University Press: New York,
1996. vi + 237 pp. ISBN 0 19 855726 4 (cloth); $85.00.
ISBN 0 19 855725 6 (paper); $37.00.
This ever-expanding area of organic chemistry is
indeed a daunting challenge for a book, both in terms of the
breadth of material and the rapid change of events relative to the
publishing time line. I feel the author has done an admirable
job juggling these two issues. Following an introductory
chapter on the principles of asymmetric induction are seven
chapters on individual classes of reactions: additions to carbonyl
compounds, alpha-substitution using chiral enolates, asymmetric
aldol reactions, additions to C-C double bonds, reduction
and oxidation, rearrangements, and hydrolysis and
esterification. The vast majority of the references are from the
mid-80s through the early 90s, including both general and
seminal references. In particular, I feel a very solid balance has
been achieved between content and clarity. The chapter on
"Principles" at the beginning was very well thought out and
organized and is a wonderful overview of asymmetric
synthesis. This is balanced nicely in subsequent chapters on
specific methods where very useful, practical generalizations are
presented, such as the "best alpha-hydroxylation" method or
the "best alpha-bromination" procedure. The chapters also have
nicely integrated examples that show the power of the
particular bond construction being examined as it applies to
published total syntheses, my favorite being the ones in the chapter
on asymmetric aldol reactions.
My only real complaint about the format is in the
difficulty of finding "past" material within the chapters,
which have no breaks or subsections. This could have been
made easier by the inclusion of subheadings.
I found this book to be very well written and truly
an enjoyable read. However, it is also very dense with
information - there are no filler sentences here! In this respect I feel that most undergraduates would find it very difficult to
follow, especially if it were a primary text for a course. It would
make a wonderful complementary text for either advanced
undergraduate courses or Master's classes, as it provides a solid
overview of this area with the major concepts and
breakthroughs clearly delineated. It would also be perfect reading for
students planning to go on to graduate school in organic chemistry.
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