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  Home > JCE Print > Journal of Chemical Education > Issues > 1999  > November  >
In the Laboratory
Parallel Combinatorial Esterification: A Simple Experiment for Use in the Second-Semester Organic Chemistry Laboratory
David M. Birney and Stephen D. Starnes
Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79409-1061
Cover
November 1999
Vol. 76 No. 11
p. 1560
Abstract
Combinatorial chemistry has revolutionized the way potential new drugs are discovered. This simple experiment utilizes the Fischer esterification, a common reaction in second-semester organic laboratories, to demonstrate the fundamentals of combinatorial methods. These include simultaneous synthesis of numerous compounds, a selective assay for a desired activity, and an algorithm for identifying the active structure. Using a parallel synthesis combinatorial method, each student in a lab section prepares a different ester. The targeted activity (the characteristic odor of wintergreen) is easily detected by smell. The student's enjoyment of the lab is enhanced by the preparation of several other characteristic odors as well.

See Letter re: this article.
Supplement
A student handout and instructor's notes are provided.
*  Contents
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More Information
*  Citation
 Birney, David M.; Starnes, Stephen D. J. Chem. Educ. 1999 76 1560.
*  Keywords
 Laboratory Instruction; Organic Chemistry; Synthesis; Natural Products; Biotechnology; Descriptive Chemistry; Organic Synthesis
*  History
 Created:
Last Updated:		 October 12, 1999
November 22, 2005
Link to Letter added (April 2004).
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