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Imidazole and Benzimidazole
Synthesis, by M. Ross Grimmett, is published by Academic Press as part of their
Best Synthetic Methods series and subseries that deals with
key systems and functional groups. There can be no doubt
that imidazoles and benzimidazoles are important systems.
They are found in nature in the amino acid histidine and are
present as structural fragments of many other naturally
occurring units. In addition there are imidazoles and bezimidazoles
that are components of important structures used in
pharmaceuticals, agrochemicals, dyestuffs, and high-temperature
polymer products. While the academic readers of this
Journal might have less occasion to look up these synthetic reactions
than research workers in the above-mentioned fields,
nevertheless this compendium can serve as a useful reference for
possible student experiments, starting materials for projects,
and general information about heterocyclic ring
construction. Indeed, the organization of the book makes the latter
utility explicit, since the chapters are labeled by the bond
being formed or the method by which the ring is constructed.
In addition, the index lists the compounds that are
discussed, so many likely compounds can be located easily.
The content of the individual chapters is typically a
brief discussion of the methodology, followed by a series of
examples and a number of recipes for the synthesis of
exemplary compounds. Every chapter is well referenced,
usually with citations numbering into the hundreds.
Although the lawyers for Academic Press put a bold face warning on the
frontispiece that "This book is not a procedural manual", it contains
many useful preps. What it does not contain is very much
mechanistic information. The author generally does not
elaborate mechanistic detail nor does he offer much speculation
about novel reactions. This is unfortunate, since he is an
experienced and authoritative investigator.
In short, this is a very nice compendium for those
interested in its subject. It is not a textbook, but it contains
good advice about synthetic strategy and many useful
preparative details. It seems probable that most of the example
recipes are taken from English language sources rather than from
the German or Japanese. Such translations would be difficult
to provide but would be an outstanding service for this kind
of book to offer.
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