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  Home > JCE Print > Journal of Chemical Education > Issues > 1999  > October  >
In the Laboratory
Chromatin Isolation and DNA Sequence Analysis in Large Undergraduate Laboratory Sections
Ann E. Hagerman
Department of Chemistry & Biochemistry, Miami University, Oxford, OH 45056
Cover
October 1999
Vol. 76 No. 10
p. 1426
Abstract
A pair of exercises that introduce undergraduate students to basic techniques and concepts of molecular biology and that are appropriate for classes with large enrollments are described. One exercise is a simple laboratory experiment in which chromatin is isolated from chicken liver and is resolved into histone proteins and DNA by ion-exchange chromatography. The other is a series of computer simulations that introduce DNA sequencing, mapping, and sequence analysis to the students. The final step of the simulation is submission of a sequence to a database on the World Wide Web for identification of the protein product of the gene.
Supplement
Details on the isolation of chromatin from chicken liver and computer simulation of the DNA sequencing are provided.
*  Contents
*  Download
supp1426.zip
More Information
*  Citation
 Hagerman, Ann E. J. Chem. Educ. 1999 76 1426.
*  Keywords
 Biochemistry; Laboratory Instruction; Biotechnology; Nucleic Acids / DNA / RNA; Proteins / Peptides; Genetics / Genetic Engineering; Computer Assisted Instruction
*  History
 Created:
Last Updated:		 9/6/1999
1/25/2006
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