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1999
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March
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In the Laboratory
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Determination of Thermodynamic Parameters of the Cyclodextrin Inclusion Processes: An Undergraduate Physical Chemistry Lab Experiment
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M. Valero, L. J. Rodriguez, and M. Mercedes Velázquez*
Universidad de Salamanca, Departmento de Química Física, Facultad de Farmacia, Apdo. 449, 37080 Salamanca, SPAIN
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March 1999
Vol. 76 No. 3
p. 418
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| Abstract |
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In this lab experiment we describe an investigation of the thermodynamics of the formation of cyclodextrin inclusion complexes by using fluorescence spectroscopy. A naphthalene derivative, 4-(6-methoxy-2-naphthyl)-2 butanone (nabumetone), was used as a guest and two different cyclodextrins, b-cyclodextrin (b-CD) and hydroxypropyl b-cyclodextrin, (HP b-CD), were used as hosts. The thermodynamic parameters of the inclusion process were determined from the temperature dependence of the association constant by using the van't Hoff relation. The results show two different behaviors depending on the nature of the host molecule. These behaviors can be discussed in terms of the nature of driving forces responsible for the interaction. The experiment is designed for physical chemistry laboratory students, although it could also be used in a high-level physical pharmacy course.
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| Supplement |
A detailed version of the laboratory experiment is available as a Microsoft document, which has been compressed into a sit file for Macintosh and a zip file for Windows. The material can also be accessed as a pdf file using Acrobat Reader.
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| More Information |
Citation |
Valero, M.; Rodriguez, L. J.; Velázquez, M. Mercedes. J. Chem. Educ. 1999 76 418.
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Keywords |
Physical Chemistry; Intermolecular Forces; UV-Vis Spectroscopy; Fluorescence Spectrometry; Thermodynamics; Drugs / Pharmaceuticals
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History |
Created:
Last Updated: |
June 15, 1999
November 22, 2005
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| Home > JCE Print > Journal of Chemical Education > Issues >
1999
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March
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418
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