JCE Online Journal of Chemical Education
 | Subscriptions  | Software Orders  | Support  | Contributors  | Advertisers  | 

JCE Print
   Current Issue
 Previous Issues
 Supplements
 Search JCE Index

JCE Digital Library
   DigiDemos
 QBank
 SymMath
 WebWare

JCE Software
   Latest Releases
 Software & Video
 Downloads
 Support

Only@JCE Online
   JCE Online Store
 JCE HS CLIC
 JCE Discussion Forums
   Biographical Snapshots
 ChemEd Resource Shelf
 Featured Molecules
 Hal's Picks
 Project Chemlab
 Reviewed WWW Sites
 "Web-Ed" Articles

About JCE
   Features
 Publications
 Operations
 Outreach
 Contact Us


  Home > JCE Print > Journal of Chemical Education > Issues > 2000  > August  >
In the Laboratory
Kinetic Isotope Effect in the Chromic Acid Oxidation of Secondary Alcohols
Charles E. Harding, Christopher W. Mitchell, and Jozsef Devenyi
Department of Chemistry, The University of Tennessee at Martin, Martin, TN 38238
Cover
August 2000
Vol. 77 No. 8
p. 1042
Abstract
The kinetic isotope effect is an invaluable tool in studying certain organic reaction mechanisms. Two activities involving the technique that are suitable for introductory organic laboratory students are described. A simple competition experiment utilizing the benzhydrolÐbenzhydrol-d1 system and chromic acid oxidation is used to demonstrate qualitatively that there is a kinetic isotope effect involved in this process. GC-MS operating in the "specific ion monitoring" mode is used for analysis. As a second experiment, a procedure for the quantitative determination of kH/kD in this system is described. The rates of oxidation of the nondeuterated and the deuterated alcohol are followed in separate reactions. Concentrations are determined by GC using an internal standard. Examples of student results for both activities are presented. Both procedures are general and may be used with other alcohols that exhibit strong molecular-ion peaks in their mass spectra. These experiments are ideal for small groups of students and are suited to being performed along with work already being done in the laboratory program.
Supplement
A competition experiment, kinetics experiment, instructor's notes, and equipment needs are included.
*  Contents
*  Download
supp1042.pdf

supp1042.sit

supp1042.zip
More Information
*  Citation
 Harding, Charles E.; Mitchell, Christopher W.; Devenyi, Jozsef. J. Chem. Educ. 2000 77 1042.
*  Keywords
 Isotopes; Kinetics; Laboratory Instruction; Mechanisms; Organic Chemistry
*  History
 Created:
Last Updated:		 July 5, 2000
August 31, 2005
<< Previous Article Table of Contents Next Article >>
  Home > JCE Print > Journal of Chemical Education > Issues > 2000  > August  > Page 1042


Subscriptions
 Subscription Info
 Order Forms

JCE HS CLIC

Our Secondary School editors work hard to distill all the JCE materials to produce a fraction of particular interest to high school teachers. We call it CLIC.
 JCE HS CLIC

Contributions Welcome
JCE welcomes your submission
 Contributors' Corner

Advertisers
In recent years we have worked hard to better match our advertisers with our readers. When shopping for chemistry education materials, visit our advertisers' WWW sites first.
 Recent Advertisers

Be An Ambassador
Take JCE along on your outreach missions. Copies of the Journal, guest access to JCE Online, our publications catalog, and more are available for your participants.
 Outreach with JCE

Comments to
jceonline@chem.wisc.edu		 Copyright © Division of Chemical Education, Inc., American Chemical Society.
All rights reserved.