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  Home > JCE Print > Journal of Chemical Education > Issues > 2000  > November  >
In the Classroom
Understanding Enzyme Inhibition
Raymond S. Ochs
Department of Pharmaceutical Sciences, St. John's University, Jamaica, NY 11439-0002
Cover
November 2000
Vol. 77 No. 11
p. 1453
Abstract
While enzyme inhibition is a widely taught subject across chemical and biochemical disciplines, it remains poorly understood. A mental image is presented to facilitate the understanding of inhibition types other than competitive. Subsequently, enzyme inhibition is developed using Vmax/Km in place of Km. Interpretation of direct (initial velocity vs substrate concentration) plots makes clear the meanings of competitive, noncompetitive, and mixed inhibition in a manner entirely distinct from current textbook treatments. The effects of inhibitors on enzymes can be seen to be reduced to a simple consideration of actions at zero and infinite substrate concentrations, corresponding to Vmax/Km and Vmax, respectively.

See Correction to this article.

See Letter re: this article.
More Information
*  Citation
 Ochs, Raymond S. J. Chem. Educ. 2000 77 1453.
*  Keywords
 Biochemistry; Enzymes; Kinetics; Teaching / Learning Aids
*  History
 Created:
Last Updated:		 October 6, 2000
April 15, 2005
Link to Correction added (May 2004). Link to Letter added (May 2004).
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