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  Home > JCE Print > Journal of Chemical Education > Issues > 2001  > April  >
In the Laboratory
Determination of Lipophilicity Constants of Sulfonamide Substituents
Maria Auxiliadôra Fontes Prado
Departamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 30180-112, Brazil
Cover
April 2001
Vol. 78 No. 4
p. 533
Abstract
This article describes a simple laboratory activity using reversed-phase thin-layer chromatography (a stationary nonpolar phase and a mobile polar phase). The Rf values determined for sulfonamides by means of reversed-phase thin-layer chromatography are used to calculate the chromatographic parameter Rm and the lipophilicity constants (p) of different substituent groups of sulfonamides. The partition coefficients (P) of sulfonamides can be calculated using the p constants and partition coefficients of sulfanilamides. This experiment offers an opportunity to demonstrate the differences between straight and reversed-phase thin-layer chromatography and introduces the chromatographic parameter Rm. It also shows how chromatography can be used to determine a very important physicochemical parameter, the partition coefficient, which is used in quantitative structure-activity relationship studies of drugs. The experiment is suitable for classes of up to about 20 students.
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*  Citation
 Prado, Maria Auxiliadôra Fontes. J. Chem. Educ. 2001 78 533.
*  Keywords
 Chromatography; Drugs / Pharmaceuticals; Laboratory Instruction; Medicinal Chemistry; Physical Chemistry
*  History
 Created:
Last Updated:		 March 2, 2001
August 31, 2005
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