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  Home > JCE Print > Journal of Chemical Education > Issues > 2001  > April  >
In the Laboratory
An Indexed Combinatorial Library: The Synthesis and Testing of Insect Repellents
William H. Miles, Kathy A. Gelato, Kristen M. Pompizzi, Aislinn M. Scarbinsky, and Brian K. Albrecht
Department of Chemistry, Lafayette College, Easton, PA 18042

Elaine R. Reynolds
Department of Biology, Lafayette College, Easton, PA 18042

Cover
April 2001
Vol. 78 No. 4
p. 540
Abstract
An indexed combinatorial library of amides was prepared by the reaction of amines and acid chlorides. A simple test for insect repellency using fruit flies (Drosophila melanogaster) allowed the determination of the most repellent sublibraries. The student-generated data were collected and analyzed to determine the most active amide(s) in the library. This experiment illustrates the fundamentals of combinatorial chemistry, a field that has undergone explosive growth in the last decade.
Supplement
Notes for the instructor and the student handout containing background information and instructions for carrying out the experiment and writing the report are available.
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*  Citation
 Miles, William H.; Gelato, Kathy A.; Pompizzi, Kristen M.; Scarbinsky, Aislinn M.; Albrecht, Brian K.; Reynolds, Elaine R. J. Chem. Educ. 2001 78 540.
*  Keywords
 Collaborative / Cooperative Learning; Drugs / Pharmaceuticals; Inquiry-Based / Discovery Method; Laboratory Instruction; Organic Chemistry; Organic Synthesis
*  History
 Created:
Last Updated:		 March 2, 2001
August 31, 2005
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