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  Home > JCE Print > Journal of Chemical Education > Issues > 2001  > August  >
In the Laboratory
The Microscale Laboratory
The Biginelli Reaction
Michael S. Holden* and R. David Crouch*
Department of Chemistry, Dickinson College, Carlisle, PA 17013-2896
Cover
August 2001
Vol. 78 No. 8
p. 1104
Abstract
The utilization of the Biginelli reaction, a one-pot condensation of an aldehyde, a b-keto ester, and urea, is described. This reaction involves a number of individual steps, each of which is accessible to first-year organic students. The product, a 3,4-dihydropyrimidinone, is a member of a medicinally useful class of compounds. The reaction is simple to perform and the product precipitates from solution in an extremely pure form.
Supplement
A student laboratory handout and instructor's notes are available.
*  Contents JCE2001p1104W.doc (MS Word)
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More Information
*  Citation
 Holden, Michael S.; Crouch, R. David. J. Chem. Educ. 2001 78 1104.
*  Keywords
 Heterocycles; Laboratory Instruction; Microscale; Organic Chemistry; Organic Synthesis
*  History
 Created:
Last Updated:		 July 10, 2001
August 31, 2005
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