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  Home > JCE Print > Journal of Chemical Education > Issues > 2001  > June  >
In the Laboratory
Combinatorial Synthesis and Discovery of an Antibiotic Compound. An Experiment Suitable for High School and Undergraduate Laboratories
Scott E. Wolkenberg and Andrew I. Su
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037
Cover
June 2001
Vol. 78 No. 6
p. 784
Abstract
An exercise demonstrating solution-phase combinatorial chemistry and its application to drug discovery is described. The experiment involves the synthesis of six libraries of three hydrazones, screening the libraries for antibiotic activity, and deconvolution to determine the active individual compound. The laboratory was designed for a high school classroom, though it can easily be expanded to suit a college introductory organic laboratory course.
Supplement
Further background material, detailed procedures for this experiment, and notes for the instructor are available.
*  Contents JCE2001p0784W.doc (Microsoft Word)
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*  Citation
 Wolkenberg, Scott E.; Su, Andrew I. J. Chem. Educ. 2001 78 784.
*  Keywords
 Aqueous Solution Chemistry; Bioorganic Chemistry; Drugs / Pharmaceuticals; Laboratory Instruction; Medicinal Chemistry; Organic Chemistry; Organic Synthesis
*  History
 Created:
Last Updated:		 May 8, 2001
August 31, 2005
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