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  Home > JCE Print > Journal of Chemical Education > Issues > 2002  > December  >
Chemistry for Everyone
Products of Chemistry
Nitrogen-Based Diazeniumdiolates: Versatile Nitric Oxide-Releasing Compounds for Biomedical Research and Potential Clinical Applications
Joseph E. Saavedra
Intramural Research Support Program, SAIC, National Cancer Institute, Frederick, MD 21702-5946

Larry K. Keefer
The Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, MD 21702-5946

Cover
December 2002
Vol. 79 No. 12
p. 1427
Abstract
Nitric oxide-generating ions of the nitrogen-diazeniumdiolate class with the general structure R1R2N-[N(O)NO]1 have been prepared by exposing primary, secondary, and polyamines to nitric oxide (NO). The resulting complexes regenerate bioactive NO at physiological pH with half-lives ranging from 2 seconds to 20 hours. An important goal in our research is to deliver NO to a specific organ or cell type where it is needed without affecting other NO-sensitive parts of the anatomy. By taking advantage of the remarkable chemical versatility of diazeniumdiolates, we have developed general strategies to prepare either tissue-selective NO donor drugs or materials containing NO delivery agents that can be physically placed near the target sites. Inhibition of blood coagulation, induction of penile erection, relief of pulmonary hypertension, and reversal of cerebral vasospasm are a few examples of their potential clinical applications.

See Featured Molecules.
More Information
*  Citation
 Saavedra, Joseph E.; Keefer, Larry K. J. Chem. Educ. 2002 79 1427.
*  Keywords
 Biochemistry; Bioinorganic Chemistry; Bioorganic Chemistry; Drugs / Pharmaceuticals; Free Radicals; Medicinal Chemistry
*  History
 Created:
Last Updated:		 October 29, 2002
March 16, 2005
Link to Featured Molecules added (April 2004).
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