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2002
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January
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In the Laboratory
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Solid-Phase Organic Synthesis and Combinatorial Chemistry: A Laboratory Preparation of Oligopeptides
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George A. Truran, Karelle S. Aiken, Thomas R. Fleming, Peter J. Webb, and J. Hodge Markgraf
Department of Chemistry, Williams College, Williamstown, MA 01267-2692
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January 2002
Vol. 79 No. 1
p. 85
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| Abstract |
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The principles and practice of solid-phase organic synthesis and combinatorial chemistry are utilized in a laboratory preparation of oligopeptides. A parallel synthesis scheme is used to generate a series of tripeptides. A divergent synthesis scheme is used to prepare two pentapeptides, one of which is leucine enkephalin, a neurotransmitter known to be an analgesic agent.
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| Supplement |
Supplemental materials are available, including: information on chemicals and equipment, purification of reagents, experimental procedures, yields, TLC data, NMR spectra, reaction mechanisms, notes for instructors, a glossary of terms, and a list of general references to SPOS and combinatorial chemistry.
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 Contents |
JCE2002p0085W.doc (Microsoft Word)
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| More Information |
Citation |
Truran, George A.; Aiken, Karelle S.; Fleming, Thomas R.; Webb, Peter J.; Markgraf, J. Hodge. J. Chem. Educ. 2002 79 85.
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Keywords |
Laboratory Instruction; Organic Synthesis; Proteins / Peptides
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History |
Created:
Last Updated: |
December 3, 2001
March 16, 2005
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| Home > JCE Print > Journal of Chemical Education > Issues >
2002
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January
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85
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