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2002
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In the Laboratory
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Experimental Design and Multiplexed Modeling Using Titrimetry and Spreadsheets
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Peter de B. Harrington, Erin Kolbrich, and Jennifer Cline
Center for Intelligent Chemical Instrumentation, Department of Chemistry & Biochemistry, Ohio University, Athens, OH 45701-2979
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July 2002
Vol. 79 No. 7
p. 863
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| Abstract |
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The topics of experimental design and modeling are important for inclusion in the undergraduate curriculum. Many general chemistry and quantitative analysis courses introduce students to spreadsheet programs, such as MS Excel. Students in the laboratory sections of these courses use titrimetry as a quantitative measurement method. Unfortunately, the only model that students may be exposed to in introductory chemistry courses is the working curve that uses the linear model. A novel experiment based on a multiplex model has been devised for titrating several vinegar samples at a time. The multiplex titration can be applied to many other routine determinations. An experimental design model is fit to titrimetric measurements using the MS Excel LINEST function to estimate concentration from each sample. This experiment provides valuable lessons in error analysis, Class A glassware tolerances, experimental simulation, statistics, modeling, and experimental design.
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| Supplement |
Documentation, which includes an introduction to linear regression analysis, instructions for additional neutralization titrations, and questions, is available.
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 Contents |
JCE2002p0863W.doc (Microsoft Word)
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| Download |
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| More Information |
Citation |
Harrington, Peter de B.; Kolbrich, Erin; Cline, Jennifer. J. Chem. Educ. 2002 79 863.
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Keywords |
Acid-Base Chemistry; Analytical Chemistry; chemometrics*; multiplexed experiments*; Statistics / Data Analysis; Stoichiometry
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History |
Created:
Last Updated: |
June 17, 2002
March 16, 2005
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