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  Home > JCE Print > Journal of Chemical Education > Issues > 2002  > March  >
Research: Science and Education
Concepts in Biochemistry
Cholesterol Biosynthesis: Lanosterol to Cholesterol
John M. Risley
Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223-0001
Cover
March 2002
Vol. 79 No. 3
p. 377
Abstract
Cholesterol is an important biochemical, medical, and commercial molecule. In the pathway for cholesterol biosynthesis, biochemistry textbooks discuss the synthesis of lanosterol from acetate in detail. However, the conversion of lanosterol to cholesterol is most often simply indicated as a multistep process, without elaboration. A pathway for the conversion of lanosterol to cholesterol, based on recent results from the primary research literature, is presented in this paper. Each reaction is discussed, the pathway is discussed within the context of general biochemical transformations, a summary of cholesterol homeostasis is presented, and enzyme deficiencies that give rise to diseases are given.
More Information
*  Citation
 Risley, John M. J. Chem. Educ. 2002 79 377.
*  Keywords
 Biochemistry; Catalysis; Enzymes; Lipids; Mechanisms; Metabolism
*  History
 Created:
Last Updated:		 January 31, 2002
March 16, 2005
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