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  Home > JCE Print > Journal of Chemical Education > Issues > 2002  > October  >
In the Laboratory
Teaching Experimental Design Using a GC–MS Analysis of Cocaine on Money: A Cross-Disciplinary Laboratory
Christopher A. Heimbuck and Nathan W. Bower
Chemistry Department, Colorado College, Colorado Springs, CO 80903-3298
Cover
October 2002
Vol. 79 No. 10
p. 1254
Abstract
The forensic analysis of cocaine on currencies was optimized using a fractional, two-level experimental design that compared methanol and HCl extraction, SPE versus heptane pre-concentration, and extracted versus total ion chromatography. Subsequent student-initiated questions about levels of cocaine on U.S. and world currencies helped make connections to societal issues while teaching method optimization and chromatography. A significant correlation was found between the levels of cocaine and the age of the bills. Levels of cocaine on various world currencies followed expected drug-trafficking patterns with the highest levels found in the most developed countries.
Supplement
Instructions for the student, procedural details, and instrumental settings are provided.
*  Contents JCE2002p1254W.doc (Microsoft Word)
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More Information
*  Citation
 Heimbuck, Christopher A.; Bower, Nathan W. J. Chem. Educ. 2002 79 1254.
*  Keywords
 Analytical Chemistry; Drugs / Pharmaceuticals; Forensic Chemistry; Instrumental Methods; Laboratory Instruction; Statistics / Data Analysis
*  History
 Created:
Last Updated:		 August 29, 2002
March 16, 2005
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