In the 4 x 4-letter matrix puzzle, each letter must be used as given by the clues associated with the number or sequence of numbers indicated in the squares. The symbols of elements are used to obtain the solution. When the puzzle is complete, the sixteen squares will contain the overlapping symbols of 46 elements and 2 isotopes. In the correct solution of the puzzle each square will contain only one letter. There is only one correct solution.
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