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2003
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February
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In the Laboratory
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A General Chemistry Laboratory Theme: Spectroscopic Analysis of Aspirin
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Houston Byrd and Stephen E. O’Donnell
Department of Biology, Chemistry, and Mathematics, University of Montevallo, Montevallo, AL 35115
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February 2003
Vol. 80 No. 2
p. 174
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| Abstract |
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In this paper, we describe the introduction of spectroscopy into the general chemistry laboratory using a series of experiments based on a common substance, aspirin. In the first lab the students synthesize and recrystallize aspirin and take melting points of their product, an aspirin standard, and salicylic acid. The students perform the remaining experiments on a rotating basis where the following four labs run simultaneously: structural characterization of the synthesized aspirin by IR and NMR; analysis of synthesized aspirin and commercial products by UV–vis spectroscopy; analysis of synthesized aspirin and commercial products by HPLC; and analysis of calcium in commercial buffered aspirin tablets by AAS. In each of the analysis experiments, students collect, graph, and analyze their data using a spreadsheet. We have found that this series of labs has been very beneficial to our students. From the course evaluations, students indicate that they are beginning to understand how chemistry is applied outside of the classroom.
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| Supplement |
Introduction, procedures, data tables, and student report forms for each experiment are available.
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 Contents |
JCE2003p0174W.doc (Microsoft Word)
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| Download |
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| More Information |
Citation |
Byrd, Houston; O’Donnell, Stephen E. J. Chem. Educ. 2003 80 174.
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Keywords |
Drugs / Pharmaceuticals; General Chemistry; Laboratory Instruction; Chromatography; NMR Spectrometry; UV-Vis Spectroscopy; Aromaticity / Aromatics; Aromaticity / Aromatics; Atomic Spectroscopy
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History |
Created:
Last Updated: |
September 7, 2001
February 28, 2005
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Link to Featured Molecules added (April 2004).
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February
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