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  Home > JCE Print > Journal of Chemical Education > Issues > 2003  > November  >
In the Classroom
Products of Chemistry
Protein Design Using Unnatural Amino Acids
Basar Bilgiçer and Krishna Kumar
Department of Chemistry, Tufts University, Medford, MA 02155
Cover
November 2003
Vol. 80 No. 11
p. 1275
Abstract
With the increasing availability of whole organism genome sequences, understanding protein structure and function is of capital importance. Recent developments in the methodology of incorporation of unnatural amino acids into proteins allow the exploration of proteins at a very detailed level. Furthermore, de novo design of novel protein structures and function is feasible with unprecedented sophistication. Using examples from the literature, this article describes the available methods for unnatural amino acid incorporation and highlights some recent applications including the design of hyperstable protein folds.
More Information
*  Citation
 Bilgiçer, Basar; Kumar, Krishna. J. Chem. Educ. 2003 80 1275.
*  Keywords
 Amino Acids; Biochemistry; Bioorganic Chemistry; Biotechnology; Organic Chemistry; Organic Synthesis; Proteins / Peptides
*  History
 Created:
Last Updated:		 October 2, 2003
February 28, 2005
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