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Some Like It Cold: Protein Structure and Function. The recent explosion of genomic sequence information available to the public presents opportunities for comparative investigations of the structure and function of proteins and enzymes. In the article "Some Like It Cold: A Computer-Based Laboratory Introduction to Sequence and Tertiary Structure Comparison of Cold-Adapted Lactate Dehydrogenases Using Bioinformatics Tools", M. Sue Lowery and Leigh A. Plesniak describe a laboratory in which sequences of the enzyme lactate dehydrogenase (LDH) from related barracuda were downloaded and compared in order to isolate mechanisms of evolutionary adaptation to differences in growth temperature.

Barracuda photograph by George Socha. LDH image provided by Leigh A. Plesniak.

The cover was designed by Betsy True.