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  Home > JCE Print > Journal of Chemical Education > Issues > 2003  > October  >
In the Laboratory
Transfer Free Energy and the Hydrophobic Effect
Joseph M. Serafin
Department of Chemistry, University of Southern Alabama, Mobile, AL 36688-0002
Cover
October 2003
Vol. 80 No. 10
p. 1194
Abstract
This laboratory experiment involves making transfer free energy measurements of probe hydrophobic molecules (toluene) in the presence of solubility modifying agents (cosolvents) commonly used in protein science. Important solution thermodynamic quantities such as activity, chemical potential, and the hydrophobic effect are discussed. This laboratory exercise is intended for students in a physical chemistry or biophysical chemistry course. The transfer free energy is determined by spectroscopic solubility measurements of the toluene in the various solutions.

See Featured Molecules.
Supplement
Detailed instructions and further discussion of background (including sample calculations) for the student, notes for the instructor, and possible discussion topics are available.
*  Contents JCE2003p1194W.doc (Microsoft Word)
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More Information
*  Citation
 Serafin, Joseph M. J. Chem. Educ. 2003 80 1194.
*  Keywords
 Biophysical Chemistry; Laboratory Instruction; Physical Chemistry; Physical Properties; Solutions / Solvents; UV-Vis Spectroscopy
*  History
 Created:
Last Updated:		 September 2, 2003
February 28, 2005
Link to Featured Molecules added (April 2004).
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