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  Home > JCE Print > Journal of Chemical Education > Issues > 2004  > February  >
In the Laboratory
Chemical Equilibrium in Supramolecular Systems as Studied by NMR Spectrometry
Gustavo González-Gaitano
Departamento de Química y Edafología (sección de Química-Física), Universidad de Navarra, 31080, Pamplona, Spain

Gloria Tardajos
Departamento de Química-Física, Facultad de Ciencias Químicas, Universidad Complutense, 28040, Madrid, Spain

Cover
February 2004
Vol. 81 No. 2
p. 270
Abstract
This experiment exposes undergraduate students to the field of supramolecular chemistry by means of an inclusion equilibrium between cyclic oligosaccharides (β- or γ-cyclodextrin) and surfactants (sodium octanoate or sodium decanoate) as studied by 1H NMR. This technique is especially suitable in molecules that neither absorb nor emit optical radiation when excited. The induced chemical shifts that occur in both guest and host protons upon inclusion give valuable structural information about the stoichiometry and geometry of the complex, and permit the estimation of the binding constants through a nonlinear least-squares analysis of selected protons of the system. The effect of the host cavity size and hydrophobicity of the surfactant on the complex stability is also discussed.
Supplement
A student handout, notes for the instructor, and MATLAB functions are available.
*  Contents JCE2004p0270W.doc (Microsoft Word)
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*  Citation
 González-Gaitano, Gustavo; Tardajos, Gloria. J. Chem. Educ. 2004 81 270.
*  Keywords
 Equilibrium; Intermolecular Forces; Laboratory Instruction; Molecular Properties / Structure; NMR Spectrometry; Physical Chemistry
*  History
 Created:
Last Updated:		 January 5, 2004
February 25, 2005
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