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  Home > JCE Print > Journal of Chemical Education > Issues > 2004  > September  >
In the Laboratory
Scaling Up Effects in the Organic Laboratory
Anna Persson and Ulf M. Lindström
Bioorganic Chemistry, Center for Chemistry and Chemical Engineering, Lund University, SE-221 00 Lund, Sweden
Cover
September 2004
Vol. 81 No. 9
p. 1353
Abstract
A simple, yet safe and effective set of experiments to expose chemistry students to some of the effects that may be encountered when scaling up an organic reaction is described. The exothermic Diels–Alder reaction between maleic anhydride and cyclopentadiene was found to be ideal for our purposes and was performed in small, medium, and large scale for comparison. The observed differences of heat evolution between the three scales were significant. Also, to demonstrate how excess heat evolution can be controlled by simple means, two additional experiments in which the reaction was run either with small glass helices or water present were performed. The experiments were combined with some simple calculations that provided graphic illustrations of the observed differences, which aided the students in their understanding of the topic. This assignment can easily be adapted to work with both small and large groups of students.
Supplement
Detailed student instructions, instructor notes, calculations, and results are available.
*  Contents JCE2004p1353W.doc (Microsoft Word)
 
*  Download



 
More Information
*  Citation
 Persson, Anna; Lindström, Ulf M. J. Chem. Educ. 2004 81 1353.
*  Keywords
 Chemical Engineering; Industrial Chemistry; Laboratory Instruction; Organic Chemistry; Organic Synthesis; Pericyclic Reactions
*  History
 Created:
Last Updated:		 July 28, 2004
August 10, 2004
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