JCE Online: Journal of Chemical Education: December 2005: Cover


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Home > Journal of Chemical Education > Issues > 2005 > December >

December 2005 Featured on the Cover

December 2005

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Issue Highlights

Human Carbonic Anhydrase II. In the laboratory "Analyzing the 3D Structure of Human Carbonic Anhydrase II and Its Mutants Using Deep View and the Protein Data Bank" by Noam J. Ship and Deborah B. Zamble, biological chemistry students critically analyze the 3D structure of a protein. The enzyme studied was human carbonic anhydrase (II) and students also examined mutants and protein bound to a variety of ligands, metals, and inhibitors. The coordinate files for each protein are downloaded by the students from the Protein Data Bank. The structure is viewed and manipulated with the public-domain molecular-viewing software Deep View. Students learn how to interpret Ramachandran plots, study familial homology, make virtual mutations, compare structures, analyze structural details, and produce stunning 3D images.

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The cover was designed by Betsy True.

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