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  Home > JCE Print > Journal of Chemical Education > Issues > 2005  > November  >
In the Laboratory
The Introduction of High-Throughput Experimentation Methods for Suzuki–Miyaura Coupling Reactions in University Education
Richard Hoogenboom, Michael A. R. Meier, and Ulrich S. Schubert
Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute, 5600 MB Eindhoven, The Netherlands
Cover
November 2005
Vol. 82 No. 11
p. 1693
Abstract
Use of high-throughput experimentation is becoming common in industry. To prepare students to work with those novel techniques in their future careers, the utilization of an automated synthesis robot was integrated into an undergraduate research project. The practical course included performing a "classical" Suzuki–Miyaura coupling reaction in the laboratory, which was subsequently converted into a step-by-step procedure suitable for fully automated parallel synthesis robots. In a next step, the power of high-throughput experimentation was demonstrated by performing 16 automated parallel Suzuki–Miyaura coupling reactions, during which the influence of solvent and base on the reaction were investigated.
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Instructions for the students and notes for the instructor are available.
*  Contents JCE2005p1693W.doc (Microsoft Word)
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*  Citation
 Hoogenboom, Richard; Meier, Michael A. R.; Schubert, Ulrich S. J. Chem. Educ. 2005 82 1693.
*  Keywords
 Aromatic Compounds; Combinatorial Chemistry; Fluorescence Spectroscopy; Graduate Education / Research; Hands-On Learning / Manipulatives; Instrumental Methods; Laboratory Equipment / Apparatus; Laboratory Instruction; NMR Spectroscopy; Organic Chemistry; Synthesis; Upper-Division Undergraduate
*  History
 Created:
Last Updated:		 9/22/2005
9/29/2005
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