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  Home > JCE Print > Journal of Chemical Education > Issues > 2006  > December  >
In the Classroom
Chemical Aspects of Local and Regional Anesthesia
Robert Brunsvold
Department of Anesthesiology, Meritcare, Fargo, ND 58123

Daryl L. Ostercamp
Department of Chemistry, Concordia College, Moorhead, MN 56562

Cover
December 2006
Vol. 83 No. 12
p. 1816
Abstract
The chemistry that underlies the development of local and regional anesthesia is explored. Starting from the first medicinal use of cocaine as a topical anesthetic in 1884, the gradual advancement of knowledge and practice until today is presented. In so far as possible, the original synthesis of each agent is included. Emphasis is placed upon the importance of acidity constants and lipophilic versus hydrophilic character in interpreting what affect a particular compound has upon biological processes. Two examples of current hospital practices are included.
More Information
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Citation
Brunsvold, Robert; Ostercamp, Daryl L. J. Chem. Educ. 2006 83 1816.
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Keywords
Acids / Bases; Analogies / Transfer; Bioorganic Chemistry; Chirality / Optical Activity; Continuing Education; Drugs / Pharmaceuticals; General Public; History / Philosophy; Medicinal Chemistry; Organic Chemistry; Public Understanding / Outreach; Second-Year Undergraduate; Synthesis; Textbooks / Reference Books
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History
Created:
Last Updated:
10/30/2006
10/31/2006
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