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  Home > JCE Print > Journal of Chemical Education > Issues > 2006  > November  >
In the Laboratory
Microwave-Mediated Synthesis of Lophine: Developing a Mechanism To Explain a Product
R. David Crouch, Jessica L. Howard, Jennifer L. Zile, and Kathryn H. Barker
Department of Chemistry, Dickinson College, Carlisle, PA 17013
Cover
November 2006
Vol. 83 No. 11
p. 1658

Abstract
The microwave-mediated preparation of lophine (2,4,5-triphenylimidazole) is described. This experiment allows for an introduction to the emerging technology of microwave-assisted organic synthesis while providing an opportunity for students to employ the principles of carbonyl chemistry in devising a mechanism to explain the formation of the product. When combined with previously published methods for heterocycle synthesis, this experiment offers an example of the advantages of microwave-assisted synthesis.
Supplement
Instructions for the students, notes for the instructor, and 1H and 13C NMR spectra are available.
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Citation
Crouch, R. David; Howard, Jessica L.; Zile, Jennifer L.; Barker, Kathryn H. J. Chem. Educ. 2006 83 1658.
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Keywords
Aldehydes / Ketones; Amines / Ammonium Compounds; Analytical Chemistry; Aromatic Compounds; Hands-On Learning / Manipulatives; Laboratory Instruction; Microscale Lab; Molecular Modeling; NMR Spectroscopy; Organic Chemistry; Second-Year Undergraduate; Synthesis
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History
Created:
Last Updated:
9/19/2006
9/20/2006
 Caution! 
Experiments, laboratory exercises, lecture demonstrations, and other descriptions of the use of chemicals, apparatus, instruments, computers, and computer interfaces are presented in the Journal of Chemical Education as illustrative of new or improved ideas or concepts in chemistry instruction and are directed at qualified teachers. Although every effort is made to assure and encourage safe practices and safe use of chemicals, the Journal of Chemical Education cannot assume responsibility for uses made of its published materials. Many chemicals are hazardous. Precautions for the safe use of hazardous chemicals and directions for their proper disposal are described in the Material Safety Data Sheets and on the labels. We strongly urge all those planning to use materials from our pages to make choices and to develop procedures for laboratory and classroom safety in accordance with local needs and situations.
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