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  Home > JCE Print > Journal of Chemical Education > Issues > 2007  > December  >
Research: Science and Education
Unequal Activities of Enantiomers via Biological Receptors: Examples of Chiral Drug, Pesticide, and Fragrance Molecules
Albrecht Mannschreck and Roland Kiesswetter
Department of Organic Chemistry, University of Regensburg, D-93040 Regensburg, Germany

Erwin von Angerer
Department of Pharmacy, University of Regensburg, D-93040 Regensburg, Germany

Cover
December 2007
Vol. 84 No. 12
p. 2012

Abstract
A molecule coming from outside an organism can form a ligand–receptor complex. Upon its formation, a message is transmitted, for example, to certain cells. In this way, two enantiomers can emit messages that differ, either quantitatively or qualitatively. In the present article, these facts are taken as a common basis for the actions of chiral drug, pesticide, and fragrance molecules. For each of these groups, a few examples of current interest were selected. At present, the demand for single enantiomers in medicine and agriculture is economically highly significant. We propose a two-hour lecture, emphasizing the similarity between the different types of receptor-mediated actions of enantiomers, thus connecting some seemingly unrelated subjects in the university curricula. The lecture is intended for medicinal chemistry students; in addition, it should be suitable for the third-year chemistry students who are interested in the applications presented here.

See JCE Featured Molecules.

Supplement
Aspects of pharmacokinetics as well as the naming and marketing of drug and pesticide enantiomers are described.
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Citation
Mannschreck, Albrecht; Kiesswetter, Roland; von Angerer, Erwin. J. Chem. Educ. 2007, 84, 2012.
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Keywords
Agricultural Chemistry; Analogies / Transfer; Biochemistry; Bioorganic Chemistry; Chirality / Optical Activity; Drugs / Pharmaceuticals; Enantiomers; Medicinal Chemistry; Organic Chemistry; Receptors; Stereochemistry; Textbooks / Reference Books; Upper-Division Undergraduate
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History
Created:
Last Updated:
10/25/2007
10/31/2007
  Home > JCE Print > Journal of Chemical Education > Issues > 2007  > December  > Page 2012


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