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  Home > JCE Print > Journal of Chemical Education > Issues > 2007  > March  >
In the Classroom
The Roles of Acids and Bases in Enzyme Catalysis
Hilton M. Weiss
Department of Chemistry, Bard College, Annandale-on-Hudson, NY 12504
Cover
March 2007
Vol. 84 No. 3
p. 440

Abstract
Many organic reactions are catalyzed by strong acids or bases that protonate or deprotonate neutral reactants leading to reactive cations or anions that proceed to products. In enzyme reactions, only weak acids and bases are available to hydrogen bond to reactants and to transfer protons in response to developing charges. Understanding this difference goes a long way toward applying organic concepts to the mechanisms of bioorganic chemistry.
More Information
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Citation
Weiss, Hilton M. J. Chem. Educ. 2007 84 440.
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Keywords
Analogies / Transfer; Biochemistry; Bioorganic Chemistry; Bronsted-Lowry Acids / Bases; Catalysis; Enzymes; Graduate Education / Research; Hydrogen Bonding; Mechanisms of Reactions; Organic Chemistry; Textbooks / Reference Books; Upper-Division Undergraduate
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History
Created:
Last Updated:
2/1/2007
2/22/2007
  Home > JCE Print > Journal of Chemical Education > Issues > 2007  > March  > Page 440


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