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  Home > JCE Print > Journal of Chemical Education > Issues > 2007  > September  >
Research: Science and Education
Products of Chemistry
The A1c Blood Test: An Illustration of Principles from General and Organic Chemistry
Robert C. Kerber
Chemistry Department, State University of New York at Stony Brook, Long Island, NY 11794-3400
Cover
September 2007
Vol. 84 No. 9
p. 1541
Abstract
The glycated hemoglobin blood test, usually designated as the A1c test, is a key measure of the effectiveness of glucose control in diabetics. The chemistry of glucose in the bloodstream, which underlies the test and its impact, provides an illustration of the importance of chemical equilibrium and kinetics to a major health problem. The reactions of glucose with proteins described in this contribution illustrate the assembly of complex organic products via simple steps (e.g., imine formation, enolization, aldol reactions, dehydrations) accessible to organic chemistry students. This material can be used to maintain or enhance student interest in courses ranging from introductory to advanced organic and physical chemistry courses.
Supplement
This set of rate constants may provide an interesting example for steady-state or numerical modeling in a physical chemistry course. A sample calculation is presented.
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Citation
Kerber, Robert C. . J. Chem. Educ. 2007, 84, 1541.
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Keywords
Applications of Chemistry; Biochemistry; Bioorganic Chemistry; Carbohydrates; First-Year Undergraduate / General; Interdisciplinary / Multidisciplinary; Mechanisms of Reactions; Organic Chemistry; Proteins / Peptides; Second-Year Undergraduate; Textbooks / Reference Books; Upper-Division Undergraduate
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History
Created:
Last Updated:
7/23/2007
8/16/2007
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