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  Home > JCE Print > Journal of Chemical Education > Issues > 2008  > February  >
In the Laboratory
A Simple Experiment in the Separation of a Solid-Phase Mixture and Infrared Spectroscopy for Introductory Chemistry
Paul S. Szalay
Department of Chemistry, Muskingum College, New Concord, OH 43762
Cover
February 2008
Vol. 85 No. 2
p. 285
Abstract
This experiment was developed as a means of incorporating instrumental analyses into an introductory chemistry laboratory. A two-component solid mixture of caffeine and ibuprofen is separated through a series of solution extractions and precipitation and their relative amounts measured. These compounds were chosen because the combination of caffeine and ibuprofen as an oral suspension has recently been investigated for pain relieving capabilities superior to those of ibuprofen alone providing a real-world context to the experiment. The solid components once recovered, dried, and weighed are analyzed using infrared spectrophotometry (IR). The goal of the IR analysis is to determine how effectively the two components were separated by comparing their spectra with the known spectra of the pure components. A guided-inquiry approach is utilized throughout the procedure for this experiment.
Supplement
A student handout that includes a detailed procedure for the experiment and sample caffeine and ibuprofen spectra obtained by students are available.
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Contents
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Citation
Szalay, Paul S. J. Chem. Educ. 2008, 85, 285.
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Keywords
Acids / Bases; Drugs / Pharmaceuticals; First-Year Undergraduate / General; Hands-On Learning / Manipulatives; Inquiry-Based / Discovery Learning; IR Spectroscopy; Laboratory Instruction; Physical Chemistry; Qualitative Analysis; Separation Science; Solutions / Solvents
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History
Created:
Last Updated:
1/4/2008
1/9/2008
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