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2008
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In the Laboratory
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Annatto Polymeric Microparticles: Natural Product Encapsulation by the Emulsion–Solvent Evaporation Method
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Zaine Teixeira and Nelson Durán
Laboratório de Química Biológica, Instituto de Química, Universidade Estadual de Campinas, BR-13084862 Campinas, SP, Brazil
Sílvia S. Guterres
Faculdade de Farmácia, Universidade Federal do Rio Grande Sul, BR-90610000 Porto Alegre, RS, Brazil
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July 2008
Vol. 85 No. 7
p. 946
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| Abstract |
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In this experiment, the extract from annatto seeds was encapsulated in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) particles by the emulsion–solvent evaporation method. The particles were washed and centrifuged to remove excess stabilizer and then freeze-dried. The main compound of annatto seeds, bixin, has antioxidant properties as well as an orange-red color. These features make annatto extract useful in the cosmetic and food industries. As an oxidant compound, bixin can readily undergo degradation. Therefore, the encapsulation of this natural product is an option to promote higher stability. In addition, a polymeric matrix can promote a sustained release of bixin molecules. The polymer employed, PHBV, is a low-cost and biodegradable material. The emulsion–evaporation method is a technique that can be used to encapsulate lipophilic molecules in a polymeric matrix. The experimental procedure involves many important concepts of colloidal chemistry such as surface tension, emulsion stability, and Ostwald ripening, among others.
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| Supplement |
Notes for instructors; Instructions for the students
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| More Information |
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Citation |
Teixeira, Zaine; Durán, Nelson; Guterres, Silvia S. J. Chem. Educ. 2008, 85, 946.
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Keywords |
Analytical Chemistry; Applications of Chemistry; Colloids; Food Science; Hands-On Learning / Manipulatives; Industrial Chemistry; Laboratory Instruction; Natural Products; Organic Chemistry; Physical Chemistry; Second-Year Undergraduate; Upper-Division Undergraduate; UV-Vis Spectroscopy
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History |
Created:
Last Updated: |
5/27/2008
6/4/2008
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 Caution! | | Experiments, laboratory exercises, lecture demonstrations, and other descriptions of the use of chemicals, apparatus, instruments, computers, and computer interfaces are presented in the Journal of Chemical Education as illustrative of new or improved ideas or concepts in chemistry instruction and are directed at qualified teachers. Although every effort is made to assure and encourage safe practices and safe use of chemicals, the Journal of Chemical Education cannot assume responsibility for uses made of its published materials. Many chemicals are hazardous. Precautions for the safe use of hazardous chemicals and directions for their proper disposal are described in the Material Safety Data Sheets and on the labels. We strongly urge all those planning to use materials from our pages to make choices and to develop procedures for laboratory and classroom safety in accordance with local needs and situations. |
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