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  Home > JCE Print > Journal of Chemical Education > Issues > 2008  > June  >
In the Laboratory
Polymer-Supported Reagents and 1H–19F NMR Couplings: The Synthesis of 2-Fluoroacetophenone
Nicola Pohl and Kimberly Schwarz
Department of Chemistry, Iowa State University, Ames, IA 50011-3111
Cover
June 2008
Vol. 85 No. 6
p. 834
Abstract
We describe an experiment for the undergraduate organic laboratory curriculum in which 2-bromoacetophenone is converted to 2-fluoroacetophenone using a solid-phase nucleophilic fluorine source. The experiment introduces students to the utility of solid-phase reagents in organic synthesis, to NMR-active nuclei other than 1H without the requirement of a special NMR probe, and to the unique uses of fluorine in molecular design.
Supplement
Student handouts; Instructor notes
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Contents
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More Information
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Citation
Pohl, Nicola; Schwarz, Kimberly. J. Chem. Educ. 2008, 85, 834.
*
Keywords
Aldehydes / Ketones; Fluorine; Hands-On Learning / Manipulatives; Laboratory Instruction; NMR Spectroscopy; Nucleophilic Substitution; Organic Chemistry; Second-Year Undergraduate; Synthesis
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History
Created:
Last Updated:
5/5/2008
5/7/2008
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