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  Home > JCE Print > Journal of Chemical Education > Issues > 2008  > May  >
In the Laboratory
Use of the Chemical Literature as a Template To Probe Stereoselective Reactions by NMR
Thomas P. Clausen, Thomas K. Green, and Benjamin Steiner
Department of Chemistry and Biochemistry, University of Alaska Fairbanks, Fairbanks, AK 99775-6160
Cover
May 2008
Vol. 85 No. 5
p. 692

Abstract
In teaching organic chemistry laboratory at this university, we eliminated the use of "canned" experiments from textbooks. Instead, we present students with literature studies that form the basis of developing new unpublished experiments to answer specific questions. In this research approach, students are better exposed to the chemical literature, gain experience in experimental design, and are forced to do more spectral interpretations rather than simply match spectra with standard spectra. Here we present two projects that are the result of this research-based approach. Both projects involved relatively advanced stereochemical concepts and one study relied on 1D or 2D NOE NMR experiments.
Supplement
Student handout; Instructor notes, including spectral data
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Contents
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Citation
Clausen, Thomas P.; Green, Thomas K.; Steiner, Benjamin. J. Chem. Educ. 2008, 85, 692.
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Keywords
Grignard Reagents; Hands-On Learning / Manipulatives; Inquiry-Based / Discovery Learning; Laboratory Instruction; NMR Spectroscopy; Organic Chemistry; Stereochemistry; Undergraduate Research; Upper-Division Undergraduate
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History
Created:
Last Updated:
3/25/2008
3/28/2008
 Caution! 
Experiments, laboratory exercises, lecture demonstrations, and other descriptions of the use of chemicals, apparatus, instruments, computers, and computer interfaces are presented in the Journal of Chemical Education as illustrative of new or improved ideas or concepts in chemistry instruction and are directed at qualified teachers. Although every effort is made to assure and encourage safe practices and safe use of chemicals, the Journal of Chemical Education cannot assume responsibility for uses made of its published materials. Many chemicals are hazardous. Precautions for the safe use of hazardous chemicals and directions for their proper disposal are described in the Material Safety Data Sheets and on the labels. We strongly urge all those planning to use materials from our pages to make choices and to develop procedures for laboratory and classroom safety in accordance with local needs and situations.
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