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  Home > JCE Print > Journal of Chemical Education > Issues > 2008  > October  >
In the Laboratory
Synthesis of the Commercial Antidepressant Moclobemide
Jesse D. More
Department of Chemistry, Loyola College, Baltimore, MD 21210
Cover
October 2008
Vol. 85 No. 10
p. 1424

Abstract
An experiment for the undergraduate organic chemistry laboratory is described in which students synthesize the commercial antidepressant drug moclobemide, marketed under the trade name Manerix. This one-step synthesis starts from commercially available material and produces moclobemide in high yield. The product is initially isolated as its hydrochloride salt via precipitation. After recrystallization and treatment with base moclobemide is isolated in pure form. The purity and identity of the product are confirmed by melting point and NMR and IR spectroscopy.
Supplement
Student handouts; Instructor notes including spectral data for moclobemide
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Contents
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Citation
More, Jesse D. J. Chem. Educ. 2008, 85, 1424.
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Keywords
Drugs / Pharmaceuticals; Hands-On Learning / Manipulatives; IR Spectroscopy; Laboratory Instruction; Medicinal Chemistry; NMR Spectroscopy; Organic Chemistry; Second-Year Undergraduate; Synthesis
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History
Created:
Last Updated:
8/27/2008
9/5/2008
 Caution! 
Experiments, laboratory exercises, lecture demonstrations, and other descriptions of the use of chemicals, apparatus, instruments, computers, and computer interfaces are presented in the Journal of Chemical Education as illustrative of new or improved ideas or concepts in chemistry instruction and are directed at qualified teachers. Although every effort is made to assure and encourage safe practices and safe use of chemicals, the Journal of Chemical Education cannot assume responsibility for uses made of its published materials. Many chemicals are hazardous. Precautions for the safe use of hazardous chemicals and directions for their proper disposal are described in the Material Safety Data Sheets and on the labels. We strongly urge all those planning to use materials from our pages to make choices and to develop procedures for laboratory and classroom safety in accordance with local needs and situations.
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