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2005
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In the Classroom
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Products of Chemistry
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Pharmaceutical Applications of Ion-Exchange Resins
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David P. Elder
GlaxoSmithKline Pharmaceuticals, Park Road, Ware, Hertfordshire SG12 0DP, United Kingdom
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April 2005
Vol. 82 No. 4
p. 575
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| Abstract |
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The historical uses of ion-exchange resins and a summary of the basic chemical principles involved in the ion-exchange process are discussed. Specific applications of ion-exchange resins are provided. The utility of these agents to stabilize drugs are evaluated. Commonly occurring chemical and physical incompatibilities are reviewed. Ion-exchange resins have found applicability as inactive pharmaceutical constituents, particularly as disintegrants (inactive tablet ingredient whose function is to rapidly disrupt the tablet matrix on contact with gastric fluid). One of the more elegant approaches to improving palatability of ionizable drugs is the use of ion-exchange resins as taste-masking agents. The selection, optimization of drug:resin ratio and particle size, together with a review of scaleup of typical manufacturing processes for taste-masked products are provided. Ion-exchange resins have been extensively utilized in oral sustained-release products. The selection, optimization of drug:resin ratio and particle size, together with a summary of commonly occurring commercial sustained-release products are discussed. Ion-exchange resins have also been used in topical products for local application to the skin, including those where drug flux is controlled by a differential electrical current (ionotophoretic delivery). General applicability of ion-exchange resins, including ophthalmic delivery, nasal delivery, use as drugs in their own right (e.g., colestyramine, formerly referred to as cholestyramine), as well as measuring gastrointestinal transit times, are discussed. Finally, pharmaceutical monographs for ion-exchange resins are reviewed.
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| More Information |
 Citation |
Elder, David P. J. Chem. Educ. 2005 82 575.
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Keywords |
disintegrants*; drug stabilization*; Drugs / Pharmaceuticals; incompatibilities*; Ion Exchange; Ion Exchange resins*; monographs*; nasal delivery*; ophthalmic delivery*; oral sustained release*; pharmaceutical excipients*; polymeric salts*; taste masking*; topical delivery*; transdermal and ionotophoretic delivery*
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History |
Created:
Last Updated: |
March 4, 2005
March 14, 2005
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| Home > JCE Print > Journal of Chemical Education > Issues >
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575
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