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  Home > JCE Print > Journal of Chemical Education > Issues > 2005  > April  >
In the Laboratory
Quantitation of Phenol Levels in Oil of Wintergreen Using Gas Chromatography–Mass Spectrometry with Selected Ion Monitoring. A Quantitative Analysis Laboratory Experiment
Robert M. Sobel, David S. Ballantine, and Victor Ryzhov
Department of Chemistry and Biochemistry, Northern Illinois University, De Kalb, IL 60115
Cover
April 2005
Vol. 82 No. 4
p. 601
Abstract
A quantitative analysis or instrumental analysis laboratory experiment was created to perform a gas chromatography–mass spectrometry analysis of phenol level found in natural products. The analysis utilizes selected ion monitoring for the determination of phenol concentration in natural oil of wintergreen. The selected ion monitoring method provides shorter analysis time while resolving components containing a m/z 94 ion. This method provides the quantitation of phenol on the order of µg/mL. The experimental design addresses the industry’s need for increasing awareness of gas chromatography–mass spectrometry techniques with shortened analysis time. Finally, the laboratory exposes students to natural-products chemistry and its applicability to analytical chemistry.
Supplement
Detailed instructor notes, including the SIM plots of the standard phenol solutions, the calibration plot, and the SIM plot of natural oil of wintergreen, and step-by-step instructions for students are available.
*  Contents JCE2005p0601W.doc (Microsoft Word)
*  Download
JCE2005p0601W.pdf

JCE2005p0601W.zip
More Information
*  Citation
 Sobel, Robert M.; Ballantine, David S.; Ryzhov, Victor. J. Chem. Educ. 2005 82 601.
*  Keywords
 Chromatography; Instrumental Methods; Laboratory Instruction; Mass Spectrometry; Natural Products
*  History
 Created:
Last Updated:		 March 4, 2005
March 14, 2005
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